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How we see the problem
Protein optimization is a search problem. The functional sequence space is enormous and the signal is sparse. In existing methods, most of this space goes untested. Random mutagenesis scales to millions of variants but stays close to a single parent sequence. Rational design reaches more diverse candidates, but has remained low-throughput due to the cost of gene synthesis.
How we solve the problem
Talaria pairs AI-guided design with in-house DNA synthesis to ship a single pool with millions of rationally designed, NGS-verified variants. By bringing both capabilities under one roof, we remove the synthesis bottleneck that has kept rational design at small scale, and enable unprecedented exploration of the functional sequence space of your protein.
Our product
We deliver a tube of DNA. Each pool contains 1,000 to 5 million rationally designed protein variants, encoded on clonable DNA fragments and verified end-to-end by next-generation sequencing. Pools are designed to drop directly into your existing high-throughput assay.
White paper
BM3 hydroxylase
- 3.2M
- Sequences designed
- 57–97%
- AA identity range
- 1053–1099 AA
- Protein length
- 3,159–3,297 BP
- DNA length
Early Access Program
Work with us
Fee-for-service. No subscription. No lock-in.
IP transfer fees waived for EAP partners.
Applications open through June 2026.
Contact
Tell us about your protein and the throughput of your assay. We’ll respond within two business days.
Or email us directly at contact@talariabio.com